GATE 2011 : Examination Syllabus
Natural Products: Pharmacognosy & Phytochemistry – Chemistry, tests,
isolation, characterization and estimation of phytopharmaceuticals belonging
to the group of Alkaloids, Glycosides, Terpenoids, Steroids, Bioflavanoids,
Purines, Guggul lipids. Pharmacognosy of crude drugs that contain the above
constituents. Standardization of raw materials and herbal products. WHO
guidelines. Quantitative microscopy including modern techniques used for
evaluation. Biotechnological principles and techniques for plant
development, Tissue culture.
Pharmacology: General pharmacological principles including
Toxicology. Drug interaction. Pharmacology of drugs acting on Central
nervous system, Cardiovascular system, Autonomic nervous system, Gastro
intestinal system and Respiratory system. Pharmacology of Autocoids,
Hormones, Hormone antagonists, chemotherapeutic agents including anticancer
drugs. Bioassays, Immuno Pharmacology. Drugs acting on the blood & blood
forming organs. Drugs acting on the renal system.
Medicinal Chemistry: Structure, nomenclature, classification,
synthesis, SAR and metabolism of the following category of drugs, which are
official in Indian Pharmacopoeia and British Pharmacopoeia. Introduction to
drug design. Stereochemistry of drug molecules. Hypnotics and Sedatives,
Analgesics, NSAIDS, Neuroleptics, Antidepressants, Anxiolytics,
Anticonvulsants, Antihistaminics, Local Anaesthetics, Cardio Vascular drugs
– Antianginal agents Vasodilators, Adrenergic & Cholinergic drugs,
Cardiotonic agents, Diuretics, Antijypertensive drugs, Hypoglycemic agents,
Antilipedmic agents, Coagulants, Anticoagulants, Antiplatelet agents.
Chemotherapeutic agents – Antibiotics, Antibacterials, Sulphadrugs.
Antiproliozoal drugs, Antiviral, Antitubercular, Antimalarial, Anticancer,
Antiamoebic drugs. Diagnostic agents. Preparation and storage and uses of
official Radiopharmaceuticals, Vitamins and Hormones. Eicosonoids and their
Pharmaceutics : Development, manufacturing standards Q.C. limits,
labeling, as per the pharmacopoeal requirements. Storage of different dosage
forms and new drug delivery systems. Biopharmaceutics and Pharmacokinetics
and their importance in formulation. Formulation and preparation of
cosmetics – lipstick, shampoo, creams, nail preparations and dentifrices.
Pharmaceutical Jurisprudence: Drugs and cosmetics Act and rules with
respect to manufacture, sales and storage. Pharmacy Act. Pharmaceutical
Pharmaceutical Analysis: Principles, instrumentation and applications
of the following: Absorption spectroscopy (UV, visible & IR). Fluorimetry,
Flame photometry, Potentiometry. Conductometry and Plarography.
Pharmacopoeial assays. Principles of NMR, ESR, Mass spectroscopy. X-ray
diffraction analysis and different chromatographic methods.
Biochemistry. Biochemical role of hormones, Vitamins, Enzymes,
Nucleic acids, Bioenergetics. General principles of immunology.
Immunological. Metabolism of carbohydrate, lipids, proteins. Methods to
determine, kidney & liver function. Lipid profiles.
Microbiology : Principles and methods of microbiological assays of
the Pharmacopoeia. Methods of preparation of official sera and vaccines.
Serological and diagnostics tests. Applications of microorganisms in Bio
Conversions and in Pharmaceutical industry.
Clinical Pharmacy : Therapeutic Drug Monitoring Dosage regimen in
Pregnancy and Lactation, Pediatrics and Geriatrics. Renal and hepatic
impairment. Drug – Drug interactions and Drug – food interactions, Adverse
Drug reactions. Medication History, interview and Patient counseling.