(Syllabus) Graduate Aptitude Test in Engineering (GATE) Syllabus | Pharmaceutical Science

Graduate Aptitude Test in Engineering (GATE) Syllabus | Pharmaceutical Science

Natural Products – Pharmacognosy & Phytochemistry: Chemistry, tests, isolation, characterization~and estimation of phytopharmaceuticals belonging to the group of Alkaloids, Glycosides, Terpenoids, Steroids, Bioflavanoids, Purines, Guggul lipids. Pharmacognosy of crude drugs which contain the above constituents. Standardisation of raw materials and herbal products. WHO guide lines. Quantitative microscopy including modern techniques used for evaluation. Biotechnological principles and techniques for plant development Tissue culture.

Pharmacology: General pharmacological principles including Toxicology. Drug interaction. Pharmacology of drugs acting on Central nervous system, Cardiovascular system, Autonomic nervous system, Gastro intestinal system and Respiratory system. Pharmacology of Autocoids, Hormones, Chemotherapeutic agents including anticancer drugs. Bioassays. Immuno Pharmacology.

Medicinal Chemistry: Structure, nomenclature, classification, synthesis, SAR and metabolism of the following category of drugs which are official in Indian Pharmacopoeia and British Pharmacopoeia Hypnotics and Sedatives, Analgesics, NSAIDS, Neuroleptics, Antidepressants, Anxiolytics, Anticonvulsants, Antihistaminics, Local anaesthetics, Cardio Vascular drugs – Antianginal agents Vasodilators, Adrenergic & cholinergic drugs, Cardiotonic agents, Diuretics, Antihypertensive drugs, Hypoglycemic agents, Antilipedmic agents, Coagulants, Anticoagulants, Antiplatelet agents. Chemotherapeutic agents – Antibiotics, Antibacterials, Sulphadrugs. Antiproliozoal drugs, Antiviral, Antitubercular, Antimalarial, Anticancer, Antiamoebic drugs. Diagnostic agents. Preparation and storage and uses of official Radiopharmaceuticals. Vitamins and Hormones.

Pharmaceutics: Development, manufacturing standards, labeling, packing as per the pharmacopoeal requirements, Storage of different dosage forms and new drug delivery systems. Biopharmaceutics and Pharmacokinetics and their importance in formulation. Formulation and preparation of cosmetics – lipstick, shampoo, creams, nail preparations and dentifrices. Pharmaceutical calculations.

Pharmaceutical Jurisprudence: Legal aspects of manufacture, storage, sale of drugs. D and C act and rules. Pharmacy act.

Pharmaceutical Analysis: Principles, instrumentation and applications of the following. Absorption spectroscopy (UV, visible & IR), Fluorimetry, Flame photometry, Potentiometry, Conductometry and Plarography. Pharmacopoeial assays. Principles of NMR, ESR, Mass spectroscopy, X-ray diffraction analysis and different chromatographic methods. Biochemistry and Clinical Pharmacy: Biochemical role of hormones, Vitamins, Enzymes, Nucleic acids. Bioenergetics. General principles of immunology. Immunological techniques. Adverse drug interaction.

Microbiology: Principles and methods of microbiological assays of the Pharmacopoeia. Methods of preparation of official sera and vaccines. Serological and diagnostic tests. Applications of microorganisms in Bio Conversions and in Pharmaceutical industry.